Endometrial receptivity test or ERA test
It is a molecular diagnostic test that allows knowing the state of receptivity of the endometrium. Thanks to this test, the chances of implantation failures are reduced, since it allows you to determine the appropriate day to perform the embryo transfer. Endometrial receptivity is necessary to achieve pregnancy, because although embryos of very good quality are achieved, if they are transferred at an inappropriate time in the cycle, implantation failure is likely to occur.
1. What is it for and for whom is it indicated?
The endometrial receptivity test is used to evaluate the state of the endometrium and determine if it has a genetic profile of receptivity or non-receptivity at the time of the biopsy.
If the endometrium is not receptive
The test allows you to locate the customized implantation window for each patient.
If the endometrium is receptive
The implantation window is on the day the biopsy was performed and the endometrium is receptive during those days. Therefore, the transfer of the embryos will be done during those same optimal days for implantation in a later cycle.
It is indicated, above all, for patients who have had implantation failure with good quality embryos.
2. Advantages of the ERA
The ERA test allows, before starting an assisted reproduction treatment, to detect the personalized implantation window of the patient. The ERA test is more sensitive than the classic method of dating endometrial status, based on histological criteria, with a high degree of subjectivity and which has been shown not to discriminate between fertile and infertile patients.
3. Endometrial Receptivity Test (ERA) Process
This molecular diagnostic tool uses NGS technology to analyze the expression of 236 genes related to the state of endometrial receptivity. It can be performed in natural or substituted cycles (when the endometrium is prepared by administering estrogen to control growth), but it cannot be performed in ovarian stimulation cycles. For this, it is necessary that the endometrial biopsy be performed by reproducing exactly the same conditions that the embryo transfer will have (medication, method of administration, etc.)
The first biopsy is performed after 5 full days of progesterone administration in a HRT (substituted) cycle, or 7 days after hCG injection in a natural cycle. Once the tissue has been collected, and deposited in a sterile container, it is kept at low temperatures until it is processed.
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